Scientists from Cold Spring Harbor Laboratory, under the leadership of Dr. Corina Amor Vegas, have conducted a new study on aging using a modified T cell method. The research, detailed in an article published in Nature, focuses on targeting and eliminating “zombie” cells in the body that accumulate with age and release toxins, contributing to age-related diseases.
The team of researchers developed genetically modified T cells that are able to recognize and destroy these zombie cells by targeting a specific protein on their surface. In experiments conducted on elderly mice, the injection of these modified T cells led to a significant slowing down of the aging process. After just 20 days, the mice showed decreased inflammation, improved metabolism, and increased mobility and energy levels.
In addition to these positive effects, the genetically modified T cells also improved blood sugar regulation in the mice. They exhibited better tolerance to increased glucose levels after meals, with decreased insulin concentration in their blood and increased insulin production after consuming sweets. These improvements are indicative of a healthy metabolism. Furthermore, the number of zombie cells significantly decreased in the liver, adipose tissue, and pancreas of the mice.
Remarkably, even young mice experienced the benefits of the single T cell injection, suggesting that the therapy may have long-lasting effects. Unlike traditional chemicals, the genetically engineered T cells can provide years of potential anti-aging benefits. This breakthrough could potentially lead to a future where a single injection is enough to prevent the development of age-related diseases for an extended period of time.
Dr. Amor Vegas emphasizes the advantages of T cells: “T cells are able to develop immunological memory and circulate for a long time in the body, unlike medicines. They are activated with the accumulation of zombies, effectively destroying them.”
Nevertheless, further research is necessary to determine the long-term effects of this therapy on humans. It is likely that repeated injections will be required to maintain the results. Additionally, potential side effects must be considered, including excessive immune reactions that can lead to dangerous complications such as exhausted immune cells, cytokine storms, or tissue necrosis. Currently, the cost of this medicine is also a factor to be taken into account. However, if proven effective and safe for human use, it may be worth the investment.
Despite being tested only on mice, Dr. Amor Vegas views this method as highly promising. She states, “Thanks to T cells, patients may not need anything except one-time treatment. A