According to a French study, taking Doxycycline after an unprotected sexual intercourse and vaccination against meningococcal B strongly reduce the risk of infection in chlamydia, syphilis or gonorrhea.
by Florence Rosier
Prevention was in the spotlight, during the 30
The concept of prevention postxposition by DoxycyCine emerged at the end of 2017, during the Ipergay test, led by the National Agency for Research on AIDS and Viral Hepatitis (ANRS). Used in the twenty-four to seventy-two hours after intercourse, this antibiotic reduced by around 70 % the risk of infection in chlamydia and syphilis.
At the same time, various epidemiological studies have reported, in recent years, that people vaccinated against meningococcal B (with the GSK Bexserto vaccine) could see the risk of gonococcal infection decrease by around 30 %. “There are common antigens between meningococcus B and gonococcus,” explains Jean-Michel Molina, head of the infectious and tropical disease service at Saint-Louis Hospital and Lariboisière Hospital (Paris-Cité University), D ‘Where possible cross protection conferred by the antimeningococcal vaccine against this ist.
No severe adverse effect
The Doxyvac study, coordinated by Jean-Michel Molina, was promoted and funded by the ANRS. Between January 2021 and July 2022, the researchers recruited 502 men’s volunteers (whose median age is 39 years) with sex with men (with a median of ten sexual partners in the last three months) and living in the region Parisian. All were under PREP (preventive HIV treatment) and had a history of STI in the previous year. They were distributed by drawing in four groups, according to the rules of “randomized” trials. The first benefited from a postxposition prevention by doxycycline (in the twenty-four to seventy hours after an unprotected sex), the second of a vaccination against meningococcus B, the third of the combination of these two interventions and the last had no intervention.
You have 47.62% of this article to read. The rest is reserved for subscribers.