Researchers from Argentina and the United States have found a patient, the body of which was completely able to get rid of the inserts of the human immunodeficiency virus (HIV) into their cells, without resorting to medical intervention. The case of Argentine, denoted by experts as “Patient Esperance” – this is the second known natural recovery worldwide. Decode of Independent Relief from HIV Article of scientists is published in the journal Annals of Internal Medicine.
HIV inserts copies of its genome in the DNA of the cell cells, creating so-called viral tanks that allow you to “hide” from immunity and medicinal and produces all new copies. However, people exist – the so-called “elite controllers” – the body of which can be successfully suppressed by HIV. They are among HIV-infected people – only 0.1-2.5 percent – and they are closely followed by scientists in the hope of finding out the mechanism of combating the virus.
In 2020, a group of researchers from the Rankov Institute managed to identify a patient, who, according to the final sequencing of millions of cells, could not find any HIV sequence, which could be used to produce a new virus – what does not say that the immunity of San Francis The patients managed to somehow destroy the viral tank. Currently, scientists together with colleagues from the University of Buenos Aires managed to detect the second patient – who did not accept antiretroviral drugs for more than eight years. Sequencing 1.19 billion cell cells and 500 million tissue cells did not find it untouched HIV inserts. Doctors revealed only seven defective provisions that were unable to replicate.
According to researchers, for both patients is probably characterized by a specific T-cell response, which allowed them to get rid of HIV. If scientists succeed in identifying and understanding their immune mechanisms, then it may be possible to develop a method for imitating it and for the other HIV-infected. Earlier to fully recover from HIV managed only after medical intervention – bone marrow transplants.