Mechanism for growth of cancer brain tumor

Researchers from the United States found an enzyme involved in the regulation of glioma cells oncoins – one of the most common and incurable types of cancer brain swollen. Article researchers Published in Clinical Cancer Research magazine.

Scientists have already known that in glyomas extremely high expression of the IIB topoisomerase enzyme (TOP2B) enzyme. This protein cuts the DNA helix, and then “inserts” it back – that, as the researchers note, allows you to interact with the fields of genome located far from each other. This in turn can afford to “turn on” oncogenes – genes that stimulate the formation of a malignant tumor.

In order to learn exactly where the enzyme carries out DNA, researchers from the North-West University using genome sequencing technologies analyzed human glioma samples. Then they were injected into glioma cells the drug etoposide, which did not allow the Top2B to insert DNA back to the genome. Scientists have found that the enzyme is present in the enhancers and promoters of the two gliome oncoins – PDGFRA and MYC. In addition, it turned out that Top2B is actively involved in the regulation of transcription of these oncogenes.

According to research, overwhelming the expression of the enzyme medication can be a perspective method of glioma therapy – however, to identify patients to which it is suitable, is still to be.

/Media reports.