Austrian researchers revealed two sugar-binding proteins that prevent SARS-COV-2 penetration into the cell. The article of scientists is published in EMBO Journal.
Pelemaker protein is one of the main mechanisms using which coronavirus penetrates into the cells of the body. Its importance for the survival and spread of the virus dictates the need for a “masking” from the cells of the immune system of the body, which is achieved at the expense of glycoilization – the connection of sugars residues – to certain protein sites.
SARS-COV-2 Peploma protein glycolization sites are one of the most conservatives in all his strains, therefore, having revealed proteins that are associated with them, you can find the protection of the Coronavirus “Achilles” for new treatments, Austrian scientists decided. The team has created and tested the library of 140 lectins – binding to the residues of protein-mammals carbohydrates. Two of them – CleC4G and CD209C – found the ability to strongly communicate with the SARS-COV-2 peleman protein, which was confirmed by studying their binding using an atomic power microscope and simulate in 3D.
Moreover, the researchers found out that these two proteins join the place of glycolization, which not only remains unchanged in all variants of the coronavirus, but it is extremely important for the work of the peleman protein – without it it becomes unstable, and the virus itself is unsuccessful. It also found that proteins lowered the contashibility coronavirus of lung cells.